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Landmark Genetic Study into health of 100,000 Nigerians Announced

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54gene, the African genomics research, services, and development company, has announced the launch of the African Centre for Translational Genomics (ACTG), an initiative established to facilitate translational genomics research by African scientists.

The establishment will also re-invest in the health ecosystem by empowering the next generation of African genomic scientists through the provision and implementation of grants, fellowships, internships and training for medical researchers, trainees and students. Additionally, the initiative will facilitate precision medicine across continental Africa. 

As a first concerted effort towards achieving its mandate, the ACTG will be funding its first study under the Non-Communicable Diseases – Genetic Heritage Study (NCD-GHS) Consortium. The consortium will see over 100,000 Nigerians participate in the eponymous study which will seek to understand the genetic basis of the highly prevalent non-Communicable Diseases (NCDs) in Nigeria such as cancers, diabetes, Alzheimer’s, chronic kidney and sickle cell disease, among others.

The consortium will have a steering committee co-led by the Director General of Nigeria Institute of Medical Research [NIMR], Prof. Babatunde Lawal Salako, the Director of National Biotechnology Development Agency’s Centre for Genomics Research and Innovation [NABDA-CGRI], Prof Oyekanmi Nash, the CEO of 54gene, Dr Abasi Ene-Obong, Dr Segun Fatumo, Assistant Professor, London School of Hygiene and Tropical Medicine [LSHTM] and Dr Omolola Salako, Consultant Oncologist, College of Medicine, University of Lagos [CMUL]. 

Speaking on the consortium launch, Dr. Abasi Ene-Obong, said, “In continuation with our belief at 54gene that genetic research in Africa should be ethical and beneficial to the communities we serve, and that African scientists be at the forefront of new drug discoveries that benefit Africans and the world at large; we have set up the ACTG to harness translational genetic research across Africa.

The NCD-GHS study is our pilot effort under the ACTG that has the potential to rewrite the playbook of genomics research, where African scientists will be placed at the forefront of new drug discoveries for conditions that affect the health of not only Nigerians, but greater Africa and the world. “

“Our collaboration with scientists at NIMR and NABDA-CGRI, as a consortium, is a highly welcome initiative which we believe will be a rewarding and mutually beneficial experience for all parties. For 54gene specifically, the opportunity for us to contribute to a broader national agenda for genomics research is both inspiring and humbling, and we are committed to ensuring its success.”

Joining Dr Ene-Obong at the launch of the NCD-GHS Consortium included many of Nigeria’s most prominent geneticists and medical research professionals; 

Professor. Babatunde Lawal Salako, Director General of the Nigeria Institute of Medical Research (NIMR), added, “Through this consortium, we aim to engage senior scientists that have made their mark in the field of cardiometabolic research in teaching hospitals across the country to ensure representativeness and quality.

We will also work with senior scientists to not only use the data from the proposed study to answer pertinent questions about the burden of cardiometabolic diseases in Nigeria as proposed in the study objectives, but also to capacitate them to conduct secondary research using already available data.”

Professor Oyekanmi Nash, Director, Genetics, Genomics and Bioinformatics at the National Biotechnology Development Agency (NABDA) noted, “NABDA-CGRI is proud to be a key partner in this consortium together with NIMR. We believe that through this consortium, we will not only be able to define the genomic epidemiology of non-communicable diseases in Nigeria, but we will also find results that would enable Nigerians to lead innovation to improve prevention, care and management of non-communicable diseases.

It is also an opportunity for NABDA-CGRI to utilize the pool of bioinformaticians it has trained over the years to build models and algorithms that would allow for robust utilisation of the genomics data expected from this initiative to support innovation.”

Dr Segun Fatumo, Assistant Professor at the London School of Hygiene and Tropical Medicine (LSHTM) and Senior Scientist at the MRC/UVRI, added, “Genomic medicine remains an important tool to provide some useful insights into the high burden of non-communicable diseases (NCDs) in Africa. I think this is our opportunity to reliably determine the distribution and prevalence of a range of NCDs in Nigeria. This study will allow us to assess the burden, spectrum and genetic determinants of NCDs.

This study would foster the development of new treatments that will benefit people living in Africa as well as people of African descent around the world. Our findings may inform public health strategies and programs in Nigeria and other African countries. Partnerships of this nature could really change the future of healthcare in Africa and other global populations.”

Dr Omolola Salako, Lecturer at College of Medicine, University of Lagos, added, “The consortium will provide an enabling environment and resource for Nigeria based scientists to develop their research capacity and skill set; as well as contribute to the ongoing efforts to improve genomics training and research in the country”

Dr Abasi Ene-Obong concluded, Consent is a prerequisite for participation in the study and we remain resolute in ensuring international research standards are maintained and exercised – ensuring best practice across the continent is implemented.”

In conclusion, the consortium leaders cited the coming together of leading scientists as a welcome development for leveraging talent from across Nigeria to promote genomics research scholarship. The genetic scientists and researchers present welcomed the initiative of the consortium and highlighted the primary intention of the body as one poised for the betterment of the health of Africans from every corner of the continent. 

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FP2030 Report Links Family Planning & Gender Equality

…The 2023 data report reveals that more women and girls than ever have access to family planning

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FP2030 Report
Source - internet: mother and child having a moment

FP2030 has launched its 2023 measurement report, Meeting the Moment: Family Planning and Gender Equality.

FP2030 Report
Dr. Martin Migombano-FP2030

The 2023 report shows significant achievements in family planning across the globe, even in the face of stagnant funding.

Speaking during the launch of the 2023 annual measurement report in Washington DC, Dr. Samukeliso Dube, FP2030 executive director, said:

“In this report, you will hear more success stories: more people than ever before are using voluntary, rights-based contraception. You will also learn more about the opportunities ahead.”

The links between family planning and gender equality are the central theme of this year’s measurement report.

The data set covers 85 countries, including for the first time Botswana and Namibia, two middle-income countries that have now made commitments to FP2030, and Jordan, which has moved into the lower-middle income category.

The report showed that in the 85 countries reviewed there are over 1 billion women of reproductive age; an estimated 377 million of those women are using a modern method of contraception, 92 million more than were using a method in 2012. 

“This year’s report comes at a critical time in our movement. We are at the intersection of several crises: globally, 800 women are dying every day in childbirth. 218 million women in the global south countries have an unmet need for modern contraception – meaning they want to avoid a pregnancy but are not using a modern method,” added Dr. Dube.

The movement for rights-based family planning is an integral part of the global push for gender equality.

Gender is at the root of every person’s ability to make and carry out decisions about sex, contraception, and sexual and reproductive health.

As the global push for gender equality gains strength, FP2030 affirms the central importance of rights-based, gender-transformative family planning. 

Dr Sheila Macharia -FP2030 Report
Dr Sheila Macharia

The report is the first to fully reflect the impact of FP2030’s move to decentralize from one secretariat in Washington DC, to five regional hubs in Nairobi, Kenya; Abuja, Nigeria; Kuala Lumpur, Malaysia; and Panama City, Panama; to ensure that the partnership is driven by regional priorities.

The report contains demographic updates from each region, as well as a special focus on postpartum family planning, a topic chosen by the Regional Hubs, as a high impact practice with demonstrated ability to improve maternal and newborn health outcomes and increase uptake of contraception.

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Cybercriminals Successfully Encrypted Data in Ransomware Attacks on Nearly 75% of Healthcare Organizations, Sophos Survey

Only 24% of Healthcare Organizations Were Able to Disrupt a Ransomware Attack Before Attackers Encrypted Their Data. This is the Lowest Rate of Disruption in 3 Years, reports SANDRA ANI

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Chester Wisniewski, director, field CTO, Sophos
Chester Wisniewski, director, field CTO, Sophos

Sophos, a global leader in innovating and delivering cybersecurity as a service, today shared its sector survey report, “The State of Ransomware in Healthcare 2023,” which revealed that, among those organizations surveyed, cybercriminals successfully encrypted data in nearly 75% of ransomware attacks.

 This is the highest rate of encryption in the past three years and a significant increase from the 61% of healthcare organizations that reported having their data encrypted last year.

In addition, only 24% of healthcare organizations were able to disrupt a ransomware attack before the attackers encrypted their data—down from 34% in 2022; this is the lowest rate of disruption reported by the sector over the past three years.

“To me, the percentage of organizations that successfully stop an attack before encryption is a strong indicator of security maturity. For the healthcare sector, however, this number is quite low—only 24%. What’s more, this number is declining, which suggests the sector is actively losing ground against cyberattackers and is increasingly unable to detect and stop an attack in progress.

“Part of the problem is that ransomware attacks continue to grow in sophistication, and the attackers are speeding up their attack timelines. In the latest Active Adversary Report for Tech Leaders, we found that the median time from the start of a ransomware attack to detection was only five days. We also found that 90% of ransomware attacks took place after regular business hours. The ransomware threat has simply become too complex for most companies to go at it alone. All organizations, especially those in healthcare, need to modernize their defensive approach to cybercrime, moving from being solely preventative to actively monitoring and investigating alerts 24/7 and securing outside help in the form of services like managed detection and response (MDR),” said Chester Wisniewski, director, field CTO, Sophos.

Healthcare Organizations Were Able to Disrupt a Ransomware Attack
Sophos report

Additional key findings from the report include:

  • In 37% of ransomware attacks where data was successfully encrypted, data was also stolen, suggesting a rise in the “double dip” method
  • Healthcare organizations are now taking longer to recover, with 47% recovering in a week, compared to 54% last year
  • The overall number of ransomware attacks against healthcare organizations surveyed declined from 66% in 2022 to 60% this year
  • Compromised credentials were the number one root cause of ransomware attacks against healthcare organizations, followed by exploits
  • The number of healthcare organizations surveyed that paid ransom payments declined from 61% last year to 42% this year. This is lower than the cross-sector average of 46%

“In 2016, the Red Cross Hospital of Córdoba in Spain suffered a ransomware attack that reached servers and encrypted hundreds of files, medical records and other important patient information. It was a major disruption to our operations and interfered with our ability to care for our patients. The stakes are high in ransomware attacks against healthcare organizations—and attackers know that—meaning we’ll always be a target. After this ransomware attack, we worked hard with Tekpyme to bolster our defenses, and now we have reduced our incident response time by 80%. I think the industry as a whole is making improvements, but there is still work to do, because of the constantly changing nature of cybercrime. Hopefully healthcare organizations can leverage the help that is available from security vendors such as Sophos to prevent a very real ‘threat to life’ if systems go offline due to a ransomware attack,” said José Antonio Alcaraz Pérez, head of information systems and communications at Cruz Red Andalusia in Spain.

“Cyberspace today is ripe with technically sophisticated actors looking for vulnerabilities to exploit. What all this translates to is a multidimensional cyberthreat of actors who have the tools to paralyze entire hospitals. Partnering with the private sector is critical to our mission. The information [they] share has real-world impacts and can save real businesses and real lives,” said Christopher Wray, FBI Director.

Sophos recommends the following best practices to help defend against ransomware and other cyberattacks:

  • Strengthen defensive shields with:
    • Security tools that defend against the most common attack vectors, including endpoint protection with strong anti-ransomware and anti-exploit capabilities
    • Adaptive technologies that respond automatically to attacks, disrupting adversaries and buying defenders time to respond
  • Optimize attack preparation, including regularly backing up, practicing recovering data from backups and maintaining an up-to-date incident response plan
  • Maintain security hygiene, including timely patching and regularly reviewing security tool configurations

To learn more about the State of Ransomware in Healthcare 2023, download the full report from Sophos.com.

*The State of Ransomware 2023 survey polled 3,000 IT/cybersecurity leaders in organizations with between 100 and 5,000 employees, including 233 from the healthcare sector, across 14 countries in the Americas, EMEA and Asia Pacific.

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LUTH Doctor Slumps And Dies After 72hrs Call In The Neurosurgery Unit

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Outrage As LUTH Doctor Dies After 72-hour Non-stop Shift

Tweeps have taken to X to share their thoughts on the death of a young doctor, identified as Dr. Umoh Michael, who died on Sunday after allegedly working 72 hours straight.

According to reports, Michael died during a church service at the United Evangelical Church on September 17. He was said to have worked a 72-hour non-stop shift at the Lagos University Teaching Hospital, Idi-Araba, where he was a resident doctor.

Doctors under the aegis of the Association of Resident Doctors, LUTH chapter, in a letter addressed to the Chief Medical Director, LUTH, Prof. Wasiu Lanre Adeyemo, attested to the fact that the young doctor was overworked.

They claimed Michael returned home at about 3:00 a.m. Sunday after a 72-hour shift in the hospital, adding that he had barely slept in their apartment before that day.

The statement partly read, “We the house officers are in deep grief over the loss of our colleague, a co-house officer (Dr Umoh Michael) who died on 17th September, 2023, after having a 72hrs call in the Neurosurgery Unit.

“He is said to have been on call 72hrs before arriving home on Sunday morning to get set for church service, reaching his worship center (United Evangelical Church) where he slumped in the church at about 11 am.”

“His roommate attested to the fact that Umoh Michael had barely slept in their apartment over the past one week as he was always on call or the day he returned home was around 3 a.m. after surgeries and other activities in the Neurosurgery Unit.”

Reacting to the sad incident, LUTH’s Public Relations Officer, Omolola Fakeye, who spoke on an online platform (not PUNCH) Online said, “It is not true that anybody worked for 72 hours. I have not been briefed about his death.

“We were at a programme yesterday (Monday), but I will find out; I can’t say anything now. I will check the medical report of what could have happened because anybody can say anything, but the medical report will show us what happened.”

May his soul rest in peace.

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